- Title
- Proteins Annexin A2 and PSA in prostate cancer biopsies do not predict biochemical failure
- Creator
- Lamb, David S.; Sondhauss, Sven; Dunne, Jonathan C.; Woods, Lisa; Delahunt, Brett; Ferguson, Peter; Murray, Judith; Nacey, John N.; Denham, James W.; Jordan, T. William
- Relation
- Anticancer research Vol. 37, Issue 12, p. 6943-6946
- Publisher Link
- http://dx.doi.org/10.21873/anticanres.12159
- Publisher
- International Institute of Anticancer Research
- Resource Type
- journal article
- Date
- 2017
- Description
- Background/Aim: We previously reported the use of mass spectrometry and western blotting to identify proteins from tumour regions of formalin-fixed paraffin-embedded biopsies from 16 men who presented with apparently localized prostate cancer, and found that annexin A2 (ANXA2) appeared to be a better predictor of subsequent biochemical failure than prostate-specific antigen (PSA). Materials and Methods: In this follow-up study, ANXA2 and PSA were measured using western blotting of proteins extracted from biopsies from 37 men from a subsequent prostate cancer trial. Results: No significant differences in ANXA2 and PSA levels were observed between men with and without biochemical failure. The statistical effect sizes were small, d=0.116 for ANXA2, and 0.266 for PSA. Conclusion: ANXA2 and PSA proteins measured from biopsy tumour regions are unlikely to be good biomarkers for prediction of the clinical outcome of prostate cancer presenting with apparently localized disease.
- Subject
- prostate cancer; proteins; FFPE sections; annexin A2; PSA
- Identifier
- http://hdl.handle.net/1959.13/1393400
- Identifier
- uon:33534
- Identifier
- ISSN:1791-7530
- Language
- eng
- Full Text
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